Maximum Amount of Data for Volume Rendering

Is there an upper limit on the amount of data that can be volume rendered? I have noticed at some point when loading a data set, based on size of data loaded, that the volume rendering just goes off the rails. It is like the stride gets all goofed up. This is on 5.9.1 on macOS 10.15.x (x86_64).

Has anybody else ever seen anything like this before?